I'm using firefox with two extensions that use the same hotkeys: Firebug (for web debugging) and del.icio.us (for online bookmarking).
After some digging I found that firebug keeps its keybinding settings in this file:
ProfileDirectory\extensions\firebug@software.joehewitt.com\content\firebug\firebugOverlay.xul
To change the default key for firebug's "Focus Command Line" command look for this line:
<key id="key_focusCommandLine" key="l" modifiers="accel,shift"
class="fbOnlyKey" command="cmd_focusCommandLine"/>
and change it to:
<key id="key_focusCommandLine" key_code="VK_F2"
class="fbOnlyKey" command="cmd_focusCommandLine"/>
And restart firefox.
Now, when you press F2 it will focus on firebug's command line.